drugset / Trial / NCT05112263
Tofacitinib Versus Cyclosporine for Steroid Refractory Acute Severe Ulcerative Colitis
Unknown
96 enrolled
Post Graduate Institute of Medical Education and Research, Chandigarh
All India Institute of Medical Sciences · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
This randomised trial plans to compare oral tofacitinib with intravenous cyclosporine in patients with acute severe ulcerative colitis who have failed to respond to intravenous steroids
Timeline
- Start
- 2023-07-01
- Primary completion
- 2025-12-01
- Completion
- 2026-06-01
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Cyclosporine | Peptide | 4 mg/kg | Intravenous |
| Subject | Tofacitinib | Small molecule | 5 mg | Oral |