A Study to Investigate the Bioavailability and Skin Absorption of CBD and THC From GT4 Technology in Healthy Adults

Phase 1 Completed 18 enrolled Gefion Canada Inc. KGK Science Inc. · collab

NaSingle-groupOpen-labelOther

Summary

The bioavailability of cannabinoids differs greatly for different routes of administration. When applied topically to the skin, they are absorbed through the skin or hair follicles while interacting with receptors to provide localized effects. To gain more information on the potential of this route of administration in therapeutic applications, this open-label study will investigate the skin absorption and bioavailability of CBD and THC delivered trans-dermally.

Timeline

Start: 2021-11-27
Primary completion: 2022-01-18
Completion: 2022-01-18

Publications

Varadi G, Zhu Z, Crowley HD, Moulin M, Dey R, Lewis ED, Evans M. Examining the Systemic Bioavailability of Cannabidiol and Tetrahydrocannabinol from a Novel Transdermal Delivery System in Healthy Adults: A Single-Arm, Open-Label, Exploratory Study. Adv Ther. 2023 Jan;40(1):282-293. doi: 10.1007/s12325-022-02345-5. Epub 2022 Oct 29.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Cannabidiol	Other / unclassified	100 mg	Topical
Subject	Δ9-tetrahydrocannabinol	Unknown	100 mg	Topical

Indications

No indication recorded.