Effect and Safety of Polyethylene Glycol Combined With Linaclotide on Colon Cleansing for Patients With Chronic Constipation

Unknown 300 enrolled Second Affiliated Hospital of Xi'an Jiaotong University

RandomizedParallel-groupSingle-blindScreening

Summary

Constipation is a common reason of poor bowel preparation, which negatively influences the quality of colonoscopy. Clinically to explore more effective and tolerant bowel clearance programs is necessary for patients with chronic constipation.

Timeline

Start: 2021-09-01
Primary completion: 2022-03-31
Completion: 2022-04-30

Publications

Wang L, Zhang Y, Li J, Ran Y, Wang X, Ma X, Yang Q, Wang F, Hu J, Zhuang K, Wang J, Quan X, Wang S, Meng R, Chen Y, Li X, Song Y, Han S, Hu H, Li L, Dai F. Efficacy of Polyethylene Glycol Electrolyte Powder Combined With Linaclotide for Colon Cleansing in Patients With Chronic Constipation Undergoing Colonoscopy: A Multicenter, Single-Blinded, Randomized Controlled Trial. Clin Transl Gastroenterol. 2024 Jun 1;15(6):e1. doi: 10.14309/ctg.0000000000000708.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Compound Polyethylene Glycol Electrolyte Powder	Unknown	3000 ml	—
Subject	Compound Polyethylene Glycol Electrolyte Powder	Unknown	4000 ml	—
Subject	Linaclotide	Peptide	290 ug	—

Indications

No indication recorded.