drugset / Trial / NCT05138276
Effect of Autologous Cord Blood Mononuclear Cells for Digestive System in Preterm Neonates
RandomizedParallel-groupOpen-labelPrevention
Summary
Pre-clinical animal studies provide robust evidence regarding the beneficial effect of stem cells for intestinal disease. This single-center, randomized, controlled, blinded trial assessed the effect of a single intravenous infusion of autologous cord blood MNCs (ACBMNCs) in preventing NEC in preterm neonates,and influence on growth and development.
Timeline
- Start
- 2021-09-01
- Primary completion
- 2022-12-31
- Completion
- 2022-12-31
Publications
- Background Ballen KK, Gluckman E, Broxmeyer HE. Umbilical cord blood transplantation: the first 25 years and beyond. Blood. 2013 Jul 25;122(4):491-8. doi: 10.1182/blood-2013-02-453175. Epub 2013 May 14.
- Background Mezey E, Nemeth K. Mesenchymal stem cells and infectious diseases: Smarter than drugs. Immunol Lett. 2015 Dec;168(2):208-14. doi: 10.1016/j.imlet.2015.05.020. Epub 2015 Jun 4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Autologous Umbilical Cord Blood Mononuclear Cells | Cell therapy | 5e+07 cells/kg | Intravenous |