drugset / Trial / NCT05140525
Effects of Combination Medical Therapy Followed by BPA on Right Ventricular-PA Coupling and Hemodynamics in CTEPH
Non-randomizedParallel-groupOpen-labelTreatment
Summary
The main goal of this study is to determine the effects of combination medical therapy (Riociguat and Macitentan) and balloon pulmonary angioplasty (BPA) on hemodynamics and right ventricular (RV) function (including advanced assessments of RV-pulmonary artery (PA) coupling from invasive hemodynamics) in participants with inoperable or post-PTE residual CTEPH.
Timeline
- Start
- 2025-01-27
- Primary completion
- 2026-12-31
- Completion
- 2026-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Macitentan | Other / unclassified | 10 mg | Oral |
| Comparator | Riociguat | Other / unclassified | 1 mg | Oral |
| Comparator | Riociguat | Other / unclassified | 2.5 mg | Oral |