drugset / Trial / NCT05148286
Albumin and Crystalloid Administration in Septic Shock
Phase 4
Recruiting
2426 enrolled
Asan Medical Center
Chungnam National University Hospital · collabGangnam Severance Hospital · collabHanyang University · collabKorea University Ansan Hospital · collabSMG-SNU Boramae Medical Center · collabSamsung Medical Center · collabSeoul National University Bundang Hospital · collabSeoul National University Hospital · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
The current guideline emphasizes fluid resuscitation as the mainstay of initial management for septic shock. Albumin has the oncotic activity to maintain intravascular volumes with additional beneficial properties in sepsis. Prior studies showed that the replacement of albumin might have survival advantages in patients with septic shock. The investigators aim to assess whether the early administration of albumin with crystalloid as initial fluid resuscitation improves survival in patients with septic shock compared to resuscitation without albumin.
Timeline
- Start
- 2022-01-17
- Primary completion
- 2027-09-30
- Completion
- 2027-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Albumin | Protein / enzyme biologic | 200 ml | — |