drugset / Trial / NCT05151484

Novel Precision Medicine Approach to Treatment of Osteoporosis Based on Bone Turnover

NCT05151484

Phase 4 Active not recruiting 60 enrolled Madhumathi Rao National Institute on Aging (NIA) · collab
RandomizedParallel-groupOpen-labelTreatment

Summary

Osteoporosis affects 24.5% of women over 65 and results in fracture-related hospital admissions exceeding those of heart attacks, strokes and breast cancer combined. Current treatment options do not account for differences between age-related and estrogen deficiency related osteoporosis, because of the need for bone biopsies for determination. This study will establish a paradigm-shifting individualized treatment protocol for age-related osteoporosis and a non-invasive method for its determination, thereby reducing the major health problems and enormous burden on society and the elderly related to this disease.

Timeline

Start
2022-03-21
Primary completion
2027-01-31
Completion
2027-01-31

Drugs

EvaluationDrugModalityDoseRoute
Comparator Alendronic Acid Small molecule 70 mg Oral
Comparator Teriparatide Protein / enzyme biologic 20 ug Subcutaneous

Indications