drugset / Trial / NCT05176418
IV Pulsed-Nicotine as a Model of Smoking: The Effects of Dose and Delivery Rate
RandomizedCrossoverDouble-blindHealth-services research
Summary
This project will examine the impact of the nicotine dose and delivery rate on nicotine's abuse potential, versus its potentially beneficial effects on smoking urges and withdrawal. Will use pulsed IV nicotine administration which closely matches nicotine delivery by inhaled tobacco use.
Timeline
- Start
- 2022-09-09
- Primary completion
- 2025-10-08
- Completion
- 2025-10-08
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Nicotine | Unknown | 0.2 mg/kg | Intravenous |
| Comparator | Nicotine | Unknown | 1 mg/kg | Intravenous |