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drugset / Trial / NCT05177419

Effects of LSD on Neuroplasticity in Healthy Subjects

NCT05177419 ↗

Phase 1 Completed 45 enrolled University of Fribourg
RandomizedCrossoverQuadruple-blindBasic science

Summary

Neuroplasticity is the brain's ability to reorganize itself and adapt in response to changing environmental conditions or pathological stimuli. LSD is a potent psychedelic drug which has been able to rapidly stimulate neuroplasticity in animal studies. Various authors have speculated that changes in neuroplasticity may contribute to LSD's long-term effects, but there is still little direct evidence that LSD or other psychedelics enhance neuroplasticity in humans. The goal of this study is to investigate the effects of LSD on several measures of neuroplasticity in healthy human subjects.

Timeline

Start
2022-05-02
Primary completion
2025-03-12
Completion
2025-03-12

Drugs

EvaluationDrugModalityDoseRoute
Comparator Lysergic Acid Diethylamide Other / unclassified 100 ug —

Indications

No indication recorded.