Nitazoxanide and Lansoprazole Based Regimens for H. Pylori Management

Summary

The study will evaluate the eradication rate and tolerability of modified LOAD regimens (three antibiotics and a proton pump inhibitor (lansoprazole)) for management of HP infection in treatment-naive patients as well as patients who failed previous therapies.

Timeline

Start

2021-10-15

Primary completion

2022-02-01

Completion

2022-03-15

Publications

• El-Azab G, Salam SA, Moustafa E, Abuoelhassan A, Shamseya A, Ellakany A, Abdelaal U, Assem M, Khalil F, Mahmoud A, Elsabaawy M, Hussein B, Ezz-Eldin M, Hassany S, Zaghloul N, Magdy M. Levofloxacin versus moxifloxacin in nitazoxanide-based quadruple therapy as a first-line treatment for Helicobacter pylori infection: NILE, a randomized, comparative, multicenter study. Sci Rep. 2026 May 18;16(1):15337. doi: 10.1038/s41598-026-51062-4.

Drugs

Indications