drugset / Trial / NCT05192486

A Study of GNC-038, a Tetra-specific Antibody, in Participants With R/R Diffuse Large B-cell Lymphoma (DLBCL)

NCT05192486

Phase 1/2 Active not recruiting 12 enrolled Sichuan Baili Pharmaceutical Co., Ltd. SystImmune Inc. · collab
NaSequentialOpen-labelTreatment

Summary

In this study, the safety and preliminary efficacy of GNC-038 in participants with recurrent or refractory Diffuse Large B-cell lymphoma (DLBCL) will be investigated to assess the dose-limiting toxicity (DLT), maximum tolerated dose (MTD) or maximum administered dose (MAD) for MTD is not reached of GNC-038. The recommended dose for phase II (RP2D) clinical study will also be determined.

Timeline

Start
2022-08-10
Primary completion
2025-12
Completion
2025-12

Drugs

EvaluationDrugModalityDoseRoute
Subject GNC-038 Monoclonal antibody Intravenous