drugset / Trial / NCT05206539

Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children

NCT05206539

Phase 3 Unknown 40 enrolled Plovdiv Medical University
RandomizedCrossoverTriple-blindTreatment

Summary

White spot lesions (WSL) are characterized by an apparently intact outer surface and a demineralized subsurface, and are considered the first clinical sign of dental caries. Aim of this study is to determine the treatment potential of self-assembling peptide (P11-4), casein phosphopeptide-amorphos calcium fluoride phosphate (CPP-ACFP) and resin infiltration technique to reverse or arrest the WSLs in the same oral environments in pediatric patients using visual assessments and laser fluorescence investigation.

Timeline

Start
2024-06-01
Primary completion
2025-03
Completion
2025-04

Drugs

EvaluationDrugModalityDoseRoute
Comparator CPP-ACFP Peptide Topical
Comparator Icon Vestibular Unknown Topical
Subject P11-4 Peptide Topical