drugset / Trial / NCT05206539
Efficacy of Different Agents in Treatment of Initial Caries on Smooth Surfaces in Permanent Teeth in Children
RandomizedCrossoverTriple-blindTreatment
Summary
White spot lesions (WSL) are characterized by an apparently intact outer surface and a demineralized subsurface, and are considered the first clinical sign of dental caries. Aim of this study is to determine the treatment potential of self-assembling peptide (P11-4), casein phosphopeptide-amorphos calcium fluoride phosphate (CPP-ACFP) and resin infiltration technique to reverse or arrest the WSLs in the same oral environments in pediatric patients using visual assessments and laser fluorescence investigation.
Timeline
- Start
- 2024-06-01
- Primary completion
- 2025-03
- Completion
- 2025-04
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | CPP-ACFP | Peptide | — | Topical |
| Comparator | Icon Vestibular | Unknown | — | Topical |
| Subject | P11-4 | Peptide | — | Topical |