drugset / Trial / NCT05211895

A Global Study to Assess the Effects of Durvalumab + Domvanalimab Following Concurrent Chemoradiation in Participants With Stage III Unresectable NSCLC

NCT05211895

Phase 3 Recruiting 860 enrolled AstraZeneca Arcus Biosciences, Inc. · collab
RandomizedParallel-groupQuadruple-blindTreatment

Summary

This is a Phase III, randomised, double-blind, placebo-controlled, multicentre, international study assessing the efficacy and safety of durvalumab (MEDI4736) and domvanalimab (AB154) compared with durvalumab plus placebo in adults with locally advanced (Stage III), unresectable NSCLC whose disease has not progressed following definitive platinum-based cCRT.

Timeline

Start
2022-02-18
Primary completion
2028-07-12
Completion
2030-10-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Domvanalimab Monoclonal antibody Intravenous
Subject Durvalumab Monoclonal antibody Intravenous