Treatment of Ocular Demodex Infestation With Topical Ivermectin Cream 1%

Summary

Patients with Demodex infestation of the eyelids will have the sleeves from both eyes cleaned off with microblepharoexfoliation. Afterwards, one eye will be randomly selected for treatment with topical ivermectin 1% cream. The treatment will be repeated on that eye 2 weeks later. Afterwards, participants will present monthly for photographs of the eyelashes. The photographs will be reviewed by an ophthalmologist outside of the study site who will be blind to which eye was treated and independently grade the amount of sleeves in each eye. The follow-up will be for 6 months after the second treatment for Group A eyes. At the 6 months point the second phase of the study will begin by treating the control eyes (now called Group B eyes) with a single application of ivermectin cream and no pre-treatment with microblepharoexfoliation.

Timeline

Start

2021-08-24

Primary completion

2023-12-31

Completion

2023-12-31

Publications

• Background Choi Y, Eom Y, Yoon EG, Song JS, Kim IH, Kim HM. Efficacy of Topical Ivermectin 1% in the Treatment of Demodex Blepharitis. Cornea. 2022 Apr 1;41(4):427-434. doi: 10.1097/ICO.0000000000002802.

Drugs

Indications

No indication recorded.