mTOR as Mediator of Insulin Sensitivity Study

Recruiting 10 enrolled University of Copenhagen Danish Diabetes Academy · collab

Non-randomizedCrossoverDouble-blindBasic science

Summary

The study investigates the role of mTOR in mediating enhancement of muscle insulin sensitivity following a single bout of exercise. This will be investigated in young healthy male subjects by administering the pharmacological mTOR inhibitor Rapamycin in a crossover blinded experimental setup known to enhance muscle insulin sensitivity following one-legged knee-extensor exercise.

Timeline

Start: 2022-02-10
Primary completion: 2029-06
Completion: 2029-06

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Sirolimus	Small molecule	16 mg	Oral

Indications

No indication recorded.