drugset / Trial / NCT05243342

A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma

NCT05243342

Phase 1 Completed 18 enrolled Genentech, Inc.
Non-randomizedSequentialOpen-labelTreatment

Summary

This study will evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with a multiple myeloma (MM)-targeting monoclonal antibody capable of inducing antibody-dependent cellular toxicity (ADCC) in participants with relapsed or refractory (R/R) MM who have received a minimum of three prior treatments, including at least one immunomodulatory drug (IMiD), one proteasome inhibitor (PI), and one anti-CD38 monoclonal antibody.

Timeline

Start
2022-04-28
Primary completion
2024-07-10
Completion
2024-07-10

Drugs

EvaluationDrugModalityDoseRoute
Subject XmAb24306 Unknown Intravenous
Background Daratumumab Monoclonal antibody Subcutaneous

Indications