drugset / Trial / NCT05243342
A Study to Evaluate the Safety and Pharmacokinetics of XMAB24306 in Combination With Daratumumab in Participants With Relapsed/Refractory Multiple Myeloma
Non-randomizedSequentialOpen-labelTreatment
Summary
This study will evaluate the safety, tolerability, pharmacokinetics, and activity of XmAb24306 in combination with a multiple myeloma (MM)-targeting monoclonal antibody capable of inducing antibody-dependent cellular toxicity (ADCC) in participants with relapsed or refractory (R/R) MM who have received a minimum of three prior treatments, including at least one immunomodulatory drug (IMiD), one proteasome inhibitor (PI), and one anti-CD38 monoclonal antibody.
Timeline
- Start
- 2022-04-28
- Primary completion
- 2024-07-10
- Completion
- 2024-07-10
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | XmAb24306 | Unknown | — | Intravenous |
| Background | Daratumumab | Monoclonal antibody | — | Subcutaneous |