Pretreatment With Unfractionated Heparin for ST Elevation Myocardial Infarction

Summary

Rupture of a coronary artery plaque leads to thrombotic occlusion of the coronary artery and would present as ST segment elevation myocardial infarction. Early treatment with aspirin and early primary percutaneous coronary intervention are indicated. Anticoagulation therapy, usually with unfractionated heparin, is required during percutaneous coronary intervention. Investigators hypothesis is that pretreatment with unfractionated heparin in addition to aspirin at first medical contact may facilitate spontaneous reperfusion of culprit artery and procedural thrombotic complication in patients with ST elevation myocardial infarction without significant risk of bleeding complications.

Timeline

Start

2022-03-10

Primary completion

2025-02-05

Completion

2025-03-05

Publications

• Fister M, Noc M, Radsel P, Bunc M, Franco D, Goslar T; HEPARIN-STEMI Trial. Prehospital Heparin Administration in Patients With STEMI Undergoing Primary PCI: HEPARIN-STEMI Randomized Controlled Trial. Circulation. 2026 May 19;153(20):1526-1534. doi: 10.1161/CIRCULATIONAHA.126.079839. Epub 2026 Mar 30.

Drugs

Indications