drugset

drugset / Trial / NCT05256069

Sex-related Differences in Sympathetic Vascular Transduction in the Setting of Hypoxemia

NCT05256069 ↗

Phase 0 Completed 31 enrolled University of Missouri-Columbia American Heart Association · collab

NaSingle-groupOpen-labelBasic science

Summary

The purpose of this project is to identify sex-related differences in the effect of hypoxia on sympathetic vascular transduction.

Timeline

Start: 2023-04-26
Primary completion: 2025-07-31
Completion: 2025-07-31

Publications

Jacob DW, Shariffi B, Bond BJ, Boyes NG, Martin SA, Gonsalves AM, Harper JL, Bostick BP, Limberg JK. beta-Adrenergic receptors mediate sex differences in vasodilation but not sympathetic-mediated vasoconstriction during hypoxia. Am J Physiol Heart Circ Physiol. 2025 Jul 1;329(1):H233-H240. doi: 10.1152/ajpheart.00192.2025. Epub 2025 Jun 4.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Propranolol	Small molecule	1 mg/kg	Oral

Indications

No indication recorded.