drugset / Trial / NCT05261360
Clinical Efficacy of Exosome in Degenerative Meniscal Injury
Phase 2
Unknown
30 enrolled
Eskisehir Osmangazi University
The Scientific and Technological Research Council of Turkey · collab
RandomizedParallel-groupOpen-labelTreatment
Summary
Comparison of intra-articular administration of synovial fluid-derived mesenchymal stem cells-derived exosomes with synovial fluid-derived mesenchymal stem cells on the same patient.
Timeline
- Start
- 2022-03
- Primary completion
- 2024-03
- Completion
- 2025-03
Publications
- Background Tegner Y, Lysholm J. Rating systems in the evaluation of knee ligament injuries. Clin Orthop Relat Res. 1985 Sep;(198):43-9.
- Background Craig CL, Marshall AL, Sjostrom M, Bauman AE, Booth ML, Ainsworth BE, Pratt M, Ekelund U, Yngve A, Sallis JF, Oja P. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003 Aug;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB.
- Background Pan H, Zhang P, Zhang Z, Yang Q. Arthroscopic partial meniscectomy combined with medical exercise therapy versus isolated medical exercise therapy for degenerative meniscal tear: A meta-analysis of randomized controlled trials. Int J Surg. 2020 Jul;79:222-232. doi: 10.1016/j.ijsu.2020.05.035. Epub 2020 Jun 6.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | SF-MSC | Cell therapy | 1 cells/kg | Other |
| Subject | SF-MSC-EX | Other / unclassified | 1 cells/kg | Other |