drugset / Trial / NCT05280873
Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of CIP
RandomizedParallel-groupOpen-labelTreatment
Summary
Checkpoint inhibitor-related pneumonitis (CIP)is a common fatal immune-related adverse event of PD-1/PD-L1 inhibitors. Some CIP patients have poor effect on hormone therapy, and the remission time of CIP varies greatly. Antifibrotic drugs may be effective in patients with CIP.
Timeline
- Start
- 2021-10-10
- Primary completion
- 2023-10-20
- Completion
- 2024-10-20
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Methylprednisolone | Other / unclassified | 2 mg/kg | — |
| Subject | Pirfenidone | Small molecule | 600 mg | — |