drugset / Trial / NCT05280873

Pirfenidone Combined With Methylprednisolone Versus Methylprednisolone in the Treatment of CIP

NCT05280873

RandomizedParallel-groupOpen-labelTreatment

Summary

Checkpoint inhibitor-related pneumonitis (CIP)is a common fatal immune-related adverse event of PD-1/PD-L1 inhibitors. Some CIP patients have poor effect on hormone therapy, and the remission time of CIP varies greatly. Antifibrotic drugs may be effective in patients with CIP.

Timeline

Start
2021-10-10
Primary completion
2023-10-20
Completion
2024-10-20

Drugs

EvaluationDrugModalityDoseRoute
Subject Methylprednisolone Other / unclassified 2 mg/kg
Subject Pirfenidone Small molecule 600 mg

Indications