Targeting Cognition in Early Alzheimer's Disease by Improving Sleep With Trazodone

Summary

To investigate the effect of trazodone on sleep, hippocampal-dependent memory and hippocampal excitability. The investigators hypothesize that trazodone will improve total sleep time and proportion of time in Slow Wave Sleep (SWS).

Timeline

Start

2023-02-02

Primary completion

2027-07-30

Completion

2028-06-30

Publications

• Eyob E, Shaw JS, Bakker A, Munro C, Spira A, Wu M, Rabinowitz JA, Peters M, Wanigatunga S, Zipunnikov V, Thompson R, Burhanullah MH, Leoutsakos JM, Rosenberg P, Greenberg B. A Randomized-Controlled Trial Targeting Cognition in Early Alzheimer's Disease by Improving Sleep with Trazodone (REST). J Alzheimers Dis. 2024;101(s1):S205-S215. doi: 10.3233/JAD-230635.

Drugs

Indications