Comparative Pharmacokinetic and Pharmacodynamic Effects of Delta-8 and Delta-9 THC

Phase 1 Completed 28 enrolled Johns Hopkins University Substance Abuse and Mental Health Services Administration (SAMHSA) · collab

RandomizedCrossoverDouble-blindBasic science

Summary

The current study will investigate the subjective, physiological, and cognitive performance effects of inhaled and orally ingested Delta-8 tetrahydrocannabinol (THC) in comparison to both placebo and Delta-9 THC. The purpose of this study is to assess the effects of Delta-8 THC as compared to placebo and Delta-9 THC. Oral fluid, urine, blood, and hair specimens will be collected from participants.

Timeline

Start: 2022-05-23
Primary completion: 2024-08-08
Completion: 2024-10-02

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Delta-8-Tetrahydrocannabinol	Other / unclassified	10 mg	Oral
Subject	Delta-8-Tetrahydrocannabinol	Other / unclassified	10 mg	Inhaled
Subject	Delta-8-Tetrahydrocannabinol	Other / unclassified	20 mg	Oral
Subject	Delta-8-Tetrahydrocannabinol	Other / unclassified	20 mg	Inhaled
Subject	Delta-8-Tetrahydrocannabinol	Other / unclassified	40 mg	Oral
Subject	Delta-8-Tetrahydrocannabinol	Other / unclassified	40 mg	Inhaled
Subject	Dronabinol	Other / unclassified	20 mg	Oral
Subject	Dronabinol	Other / unclassified	20 mg	Inhaled

Indications

No indication recorded.