drugset / Trial / NCT05292742
Compare Continuation of Original Targeted Therapy With Trastuzumab Combined With Pyrotinib and Capecitabine as Postoperative Adjuvant Therapy in Non-pCR Patients With HER2 Positive Early Breast Cancer
RandomizedParallel-groupOpen-labelTreatment
Summary
To evaluate the efficacy of continuation targeted therapy compared with trastuzumab combined with Pyrotinib and capecitabine in postoperative adjuvant therapy of HER-2 positive early breast cancer patients with residual tumor (primary breast tumor/axillary lymph nodes) who did not achieve pCR after neoadjuvant therapy
Timeline
- Start
- 2021-07-02
- Primary completion
- 2026-10-01
- Completion
- 2027-12-31
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Capecitabine | Small molecule | 1000 mg/m2 | Oral |
| Comparator | Pertuzumab | Monoclonal antibody | 420 mg | — |
| Subject | Pyrotinib | Small molecule | 400 mg | Oral |
| Comparator | Trastuzumab | Monoclonal antibody | 6 mg/kg | — |