Safety and Tolerability of the Use of Copaiba in Patients With Oral Cancer Submitted to Radiotherapy

Summary

This study aims to propose an alternative and auxiliary methodology for the prevention and treatment of Oral Mucositis (OM) in patients undergoing radiotherapy or radio and chemotherapy for head and neck neoplasms through the use of copaiba-based mouthwash, since the treatment that currently has proven efficacy for the prevention of OM(Low Power Laser Therapy) cannot be applied in tumor regions due to the risk of stimulating the tissue proliferation of malignant cells.

Timeline

Start

2021-05-11

Primary completion

2025-09-07

Completion

2026-12

Publications

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• Background Leandro LM, Vargas Fde S, Barbosa PC, Neves JK, da Silva JA, da Veiga-Junior VF. Chemistry and biological activities of terpenoids from copaiba (Copaifera spp.) oleoresins. Molecules. 2012 Mar 30;17(4):3866-89. doi: 10.3390/molecules17043866.
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• Background Tobouti PL, de Andrade Martins TC, Pereira TJ, Mussi MCM. Antimicrobial activity of copaiba oil: A review and a call for further research. Biomed Pharmacother. 2017 Oct;94:93-99. doi: 10.1016/j.biopha.2017.07.092. Epub 2017 Jul 27.
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• Background Valadas LAR, Gurgel MF, Mororo JM, Fonseca SGDC, Fonteles CSR, de Carvalho CBM, Fechine FV, Rodrigues Neto EM, de Franca Fonteles MM, Chagas FO, Lobo PLD, Bandeira MAM. Dose-response evaluation of a copaiba-containing varnish against streptococcus mutans in vivo. Saudi Pharm J. 2019 Mar;27(3):363-367. doi: 10.1016/j.jsps.2018.12.004. Epub 2018 Dec 15.
• Background Wagner VP, Webber LP, Ortiz L, Rados PV, Meurer L, Lameira OA, Lima RR, Martins MD. Effects of Copaiba Oil Topical Administration on Oral Wound Healing. Phytother Res. 2017 Aug;31(8):1283-1288. doi: 10.1002/ptr.5845. Epub 2017 Jun 21.
• Background Yarom N, Ariyawardana A, Hovan A, Barasch A, Jarvis V, Jensen SB, Zadik Y, Elad S, Bowen J, Lalla RV; Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society of Oral Oncology (MASCC/ISOO). Systematic review of natural agents for the management of oral mucositis in cancer patients. Support Care Cancer. 2013 Nov;21(11):3209-21. doi: 10.1007/s00520-013-1869-5. Epub 2013 Jun 14.
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