Investigation of Intranasal Ketamine Related Changes in Attentional Brain Networks With Functional and Structural MRI

Summary

Subanesthetic ketamine is currently used as a rapid-acting antidepressant. It is an antagonist of the N-methyl-d-aspartate (NMDA) receptor, but former results indicate that its action also depends on the noradrenaline system and the locus coeruleus (LC). Based on this known impact of ketamine on the sympathetic nervous system the aim of this study is to investigate the effects of intranasal esketamine on LC related attentional brain networks in task based functional MRI, to relate those attention network changes to behavioural measures and to predict ketamine related attention network changes by brain structure.

Timeline

Start

2022-06-01

Primary completion

2023-06-21

Completion

2023-06-21

Publications

• Klobl M, Liebe T, Dorl G, Stohrmann P, Schmidt C, Briem E, Milz C, Schlosser G, Kathofer M, Gomola D, Godbersen GM, Crone JS, Lanzenberger R, Spies M. Sex, drugs, and arousal-two randomized trials on the effects of ketamine on sexual arousal and calcarine gyrus activity. Ther Adv Psychopharmacol. 2026 Feb 12;16:20451253251406059. doi: 10.1177/20451253251406059. eCollection 2026.

Drugs

Indications

No indication recorded.