Effect of Different Antihypertensive Drugs on Central Blood Pressure

Summary

Trial name) The differential effects of antihypertensive drugs on central blood pressure: comparison between beta-blocker(BB) and angiotensin receptor blocker ARB) Objectives) To evaluate the effect of BB, which has vasodilatory effects, on CBP by comparison between ARB, one of the most widely used class of antihypertensives. Study design) A multicenter, prospective, randomized, controlled, open-label clinical trial for hypertension patients. Patient enrollment) 110 patients will be enrolled at 2 centers in South Korea. Patient follow-up) Patients will go through an initial washout period of two weeks prior to randomization. After pre-medication baseline visit and randomization, clinical follow-up will occur at 4, 8, 12 weeks after initial administration of randomized drug. The follow-up visits are office visits. Primary endpoint) Reduction in CBP at 12 weeks. Secondary endpoints) Clinical events including adverse reactions to the drugs.

Timeline

Start

2019-01-06

Primary completion

2022-12

Completion

2026-03

Publications

• Lim S, Kook H, Yu CW, Kim JH, Cha JJ, Joo HJ, Na JO, Choi CU, Lim SY, Park JH, Hong SJ, Lim DS. Differential Effects of Antihypertensive Drugs on Central Blood Pressure: A Randomized Comparison Between Nebivolol and Telmisartan. Am J Hypertens. 2026 Feb 1;39(2):303-311. doi: 10.1093/ajh/hpaf098.

Drugs

Indications