IL-6 Regulation of Energy Stores During Recovery From an Acute Exercise Bout

Summary

The aim of the study is to investigate the role of exercise-induced IL-6 in regulating energy stores and energy metabolism during recovery after an acute exercise bout. To achieve this, 30 men will be randomized to infusion placebo or tocilizumab (IL-6 receptor antibody) combined with a 2-hour exercise bout. Stable isotope tracers will be infused to determine substrate kinetics. Indirect calorimetry will be applied to determine substrate oxidation, and muscle biopsies will be taken to determine substrate uptake and storage.

Timeline

Start

2022-04-20

Primary completion

2022-10-11

Completion

2022-10-11

Publications

• Kistner TM, Trinh B, Mfeketo K, van Hall G, Pedersen BK, Lieberman DE, Ellingsgaard H. Myokine IL-6 activity enhances post-exercise fatty acid accumulation in skeletal muscle but does not affect glycogen resynthesis. Mol Metab. 2026 Jan;103:102283. doi: 10.1016/j.molmet.2025.102283. Epub 2025 Nov 14.

Drugs

Indications

No indication recorded.