Myopia Intervention in Children and Adolescents and Establishment of a Precise Intervention Model

Phase 4 Unknown 186 enrolled Shanghai Eye Disease Prevention and Treatment Center Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine · collab Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University · collab

RandomizedParallel-groupTriple-blindTreatment

Summary

Investigators are going to conduct a multi-centered randomized clinical trial that myopic children are randomly allocated into three groups: 0.01% atropine， 0.04% atropine and orthokeratology in order to evaluate the efficacy and side effects of different intervention methods and establish a risk factor model to predict the efficacy of myopia intervention, and to provide precise intervention plans and clinical decisions for the control of myopia.

Timeline

Start: 2021-07-01
Primary completion: 2023-07-01
Completion: 2023-08-31

Publications

Xu H, Chen M, Ye L, Shu Q, Peng Y, Liang X, Yu T, Ji Y, Li S, Shen Q, He J, Li L, Zhu J, Xu X. Orthokeratology, 0.04% Atropine, and 0.01% Atropine for Myopia Control: A Randomized Clinical Trial. JAMA Ophthalmol. 2025 Jul 24;143(9):731-8. doi: 10.1001/jamaophthalmol.2025.2321. Online ahead of print.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Atropine	Other / unclassified	0.01 %	Other
Subject	Atropine	Other / unclassified	0.04 %	Other

Myopia Intervention in Children and Adolescents and Establishment of a Precise Intervention Model

Summary

Timeline

Publications

Drugs

Indications