drugset / Trial / NCT05366179

Autologous CAR-T Cells Targeting B7-H3 in Recurrent or Refractory GBM CAR.B7-H3Tc

NCT05366179 ↗

Phase 1 Recruiting 36 enrolled UNC Lineberger Comprehensive Cancer Center
NaSingle-groupOpen-labelTreatment

Summary

The purpose of this study is to test the safety of using T lymphocyte chimeric antigen receptor cells against the B7-H3 antigen (CAR.B7-H3T cells) in patients with glioblastoma. CAR.B7-H3T cells treatment has not been tested in humans and is not an approved treatment by the Food and Drug Administration for glioblastoma.

Timeline

Start
2022-09-02
Primary completion
2030-05-30
Completion
2030-05-30

Drugs

EvaluationDrugModalityDoseRoute
Subject CAR.B7-H3T cells Cell therapy 2e+06 cells Intravitreal
Subject CAR.B7-H3T cells Cell therapy 5e+06 cells Intravitreal

Indications