Effect of Midazolam Premedication on Mask Ventilation Difficulty
Summary
Mask ventilation has great importance during anesthesia induction because it is the only way to oxygenate patients who have lost consciousness and spontaneous breathing. Adequate muscle relaxation and depth of anesthesia may assist with mask ventilation. It is known that premedication to reduce anxiety has a relaxing effect on airway muscles. Midazolam is frequently used in premedication because it has a rapid onset of action and does not cause hemodynamic changes. In addition, midazolam may relax the airway by acting directly on the airway smooth muscle and thus facilitate mask ventilation during anesthesia induction. In this study, we will conduct a randomized controlled trial to evaluate the effect of midazolam premedication on facilitating mask ventilation in children.
Timeline
- Start
- 2022-05-24
- Primary completion
- 2022-12-07
- Completion
- 2022-12-07
Outcome
Met primary endpoint
paper According to the Han mask grading scale, the scores of the patients in the midazolam group were significantly lower than those of the control group. PMID 40102763 ↗
paper The distribution of Han scores was significantly different between the groups (p < 0.001). PMID 40102763 ↗
paper In conclusion, the results of this clinical research demonstrated that midazolam premedication improves mask ventilation in children during general anesthesia induction. PMID 40102763 ↗
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Midazolam | Small molecule | 0.1 mg/kg | Intravenous |
Indications
No indication recorded.