drugset / Trial / NCT05369000
Trial of LAVA-1207 in Patients With Therapy Refractory Metastatic Castration Resistant Prostate Cancer (mCRPC) Resistant Prostate Cancer
Non-randomizedSequentialOpen-labelTreatment
Summary
This is a phase 1, first-in-human study to evaluate Safety, Tolerability, PK, PD, Immunogenicity, and Antitumor Activity of LAVA-1207 alone or with low dose interleukin-2 or Pembrolizumab, in patients with therapy refractory metastatic castration resistant prostate cancer.
Timeline
- Start
- 2022-01-17
- Primary completion
- 2025-06-18
- Completion
- 2025-06-18
Outcome
Outcome not reported
Stopped: “The trial was intended to be a Phase 1/2 trial (but the trial never moved forward to Phase 2).”
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | LAVA-1207 | Other / unclassified | — | Intravenous |
| Subject | Pembrolizumab | Monoclonal antibody | — | Intravenous |