drugset / Trial / NCT05377619

Preventing Gastric Glitch With Prucalopride and Buspirone: N-of-1 Clinical Trial

NCT05377619

Phase 1/2 Completed 1 enrolled Universidade de Passo Fundo
RandomizedSequentialDouble-blindPrevention

Summary

Background: Gastric glitch is a new functional disease characterized by severe and transient epigastric pain occurring after challenges such as drinking alcohol and eating specific foods. Aims: In this N-of-1 trial, we first characterized the clinical and gastric tomographic images of a patient with gastric glitch highly reproducible after alcohol challenging, and then tested the effect of prucalopride and buspirone on the prevention of gastric glitch crises.

Timeline

Start
2022-01-06
Primary completion
2022-03-06
Completion
2022-03-06

Drugs

EvaluationDrugModalityDoseRoute
Subject Buspirone Small molecule 10 mg Oral
Subject Prucalopride Small molecule 2 mg Oral

Indications