drugset / Trial / NCT05379322

The Use of Synovial Biopsies in Predicting Response to Biologic Therapy in Rheumatoid Arthritis Patients

NCT05379322

Phase 3 Withdrawn Abu Dhabi Stem Cells Center
RandomizedParallel-groupOpen-labelTreatment

Summary

SYBRA is an open-label, phase 3, randomized controlled clinical trial that aims to assess the use of synovial biopsies in predicting response to biologic therapy in patients with rheumatoid arthritis that have failed disease-modifying drugs. The project has the potential to help change the current practice by offering the best treatment option. The decision to choose the best treatment for a particular patient is especially important in the context of the growing number of therapies available as a first-line option and the lack of specific biomarkers to predict response to treatment.

Timeline

Start
2023-03-01
Primary completion
2023-03-01
Completion
2023-03-01

Drugs

EvaluationDrugModalityDoseRoute
Subject Adalimumab Monoclonal antibody
Subject Baricitinib Small molecule
Subject Certolizumab Protein / enzyme biologic
Subject Etanercept Protein / enzyme biologic
Subject Golimumab Monoclonal antibody
Subject Tofacitinib Small molecule
Subject Upadacitinib Small molecule

Indications