drugset / Trial / NCT05407285
A Study of Ingested Cannabidiol in Healthy Occasional Cannabis Users
RandomizedCrossoverQuadruple-blindTreatment
Summary
The purposes of this study are 1) to determine if the administration of different low doses of oral CBD (20 mg, 50 mg, 100 mg and 200 mg) result in detectable subjective pleasant drug effect compared to placebo and 2) to qualitatively explore whether low dose of oral CBD is associated with effects that are not detected with the available research tools.
Timeline
- Start
- 2022-07-22
- Primary completion
- 2023-11-14
- Completion
- 2023-11-14
Publications
- Chester LA, Hebert FO, Lachance-Touchette P, Mahroug A, Abboud A, McCrea TP, Mansour S, Marsan S, Jutras-Aswad D. Acute behavioural effects of low-dose cannabidiol: A randomised crossover trial in healthy volunteers. J Psychopharmacol. 2026 Jul 15:2698811261464527. doi: 10.1177/02698811261464527. Online ahead of print.
- Abboud A, Chester LA, Hebert FO, Jutras-Aswad D. Sex-specific association between low oral doses of cannabidiol (CBD) and plasma concentration of anandamide (AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA) in healthy occasional cannabis users. J Cannabis Res. 2026 Jan 9;8(1):20. doi: 10.1186/s42238-025-00356-x.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Cannabidiol | Other / unclassified | 20 mg | Oral |
| Subject | Cannabidiol | Other / unclassified | 50 mg | Oral |
| Subject | Cannabidiol | Other / unclassified | 100 mg | Oral |
| Subject | Cannabidiol | Other / unclassified | 200 mg | Oral |