drugset
drugset / Trial / NCT05408000

Comparision of Motor Seizure Duration of Ketofol and Propofol for Electroconvulsive Therapy

NCT05408000 ↗

Completed 54 enrolled Tribhuvan University Teaching Hospital, Institute Of Medicine.
RandomizedParallel-groupTriple-blindTreatment

Summary

Propofol is routinely used in our hospital for ECT. It causes hypotension and has anticonvulsant actions. Use of ketofol ( 1:1 combination of ketamine and propofol) during ECT can have longer seizure duration and better hemodynamics than propofol alone which ultimately leads to better therapeutic efficacy. Motor seizure duration of minimum 20-25 seconds is usually recommended for therapeutic efficacy of ECT.Patients planned for electroconvulsive therapy meeting the inclusion criteria and not having exclusion criteria will be randomized into two groups. Group K will receive titrated dose of Ketofol and Group P will receive titrated dose of Propofol for induction of anaesthesia

Timeline

Start
2021-01-01
Primary completion
2021-06-15
Completion
2021-06-15

Drugs

EvaluationDrugModalityDoseRoute
Comparator Ketamine Small molecule 0.25 mg/kg —
Comparator Propofol Small molecule 0.25 mg/kg —
Comparator Propofol Small molecule 0.5 mg/kg —

Indications

No indication recorded.