Evaluating Smoking Cessation Interventions for PWH in South Africa

Phase 2/3 Recruiting 660 enrolled Johns Hopkins University Colorado State University · collab National Cancer Institute (NCI) · collab New York University · collab Perinatal HIV Research Unit of the University of the Witswatersrand · collab

RandomizedFactorialOpen-labelTreatment

Summary

The overall objective of the study is to optimize a smoking cessation treatment package for people with HIV (PWH) that can be integrated into existing HIV care in South Africa.

Timeline

Start: 2023-11-27
Primary completion: 2027-08-31
Completion: 2027-08-31

Publications

Genade LP, Steiner L, Nabeemeeah F, Niaura RS, Nonyane BAS, Hoffmann CJ, Sohn H, Kemp CG, Guastaferro K, Mlambo L, Chetty D, Waja Z, Martinson N, Golub JE, Elf JL. Evaluating smoking cessation interventions for people living with HIV in a factorial randomised clinical trial in South Africa using the Multiphase Optimization Strategy (MOST) framework: The Tlogela Trial protocol. Contemp Clin Trials. 2025 Aug;155:107985. doi: 10.1016/j.cct.2025.107985. Epub 2025 Jun 19.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Nicotine gum	Other / unclassified	—	—
Subject	Nicotine patch	Unknown	—	—
Subject	Varenicline	Small molecule	—	—

Evaluating Smoking Cessation Interventions for PWH in South Africa

Summary

Timeline

Publications

Drugs

Indications