Deprescribing Tamsulosin in Older Men

Phase 4 Completed 31 enrolled University of California, San Francisco National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · collab

RandomizedCrossoverQuadruple-blindTreatment

Summary

This is a pilot 12-week randomized, placebo-controlled N-of-1 deprescribing trial among older men receiving chronic tamsulosin therapy for lower urinary tract symptoms attributed to benign prostatic hyperplasia.

Timeline

Start: 2021-09-18
Primary completion: 2022-07-22
Completion: 2022-07-22

Publications

Bauer SR, Kenfield SA, Oni-Orisan A, Shlipak MG, Lu K, Rios N, Pearce R, Harmon J, McCulloch CE, Huang L, Steinman MA, Breyer BN. Tamsulosin Deprescribing for Lower Urinary Tract Symptoms in Older Men: A Randomized Clinical Trial. JAMA Netw Open. 2026 Jul 1;9(7):e2621639. doi: 10.1001/jamanetworkopen.2026.21639.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Tamsulosin	Other / unclassified	0.4 mg	—
Subject	Tamsulosin	Other / unclassified	0.8 mg	—

Deprescribing Tamsulosin in Older Men

Summary

Timeline

Publications

Drugs

Indications