drugset / Trial / NCT05418049
Evaluating the Neurophysiologic and Clinical Effects of Single Dose Drug Challenge
Phase 2
Active not recruiting
45 enrolled
Children's Hospital Medical Center, Cincinnati
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · collab
RandomizedCrossoverOpen-labelBasic science
Summary
The aim of this study is to utilize neurophysiologic assessments, behavioral measures and clinical measures to assess how much deficits associated with Fragile X Syndrome from pre-dose to post-dose using pharmacology.
Timeline
- Start
- 2022-09-08
- Primary completion
- 2025-10-28
- Completion
- 2026-03-05
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Subject | Baclofen | Small molecule | 30 mg | — |
| Subject | Memantine | Unknown | 20 mg | — |
| Subject | Roflumilast | Small molecule | 250 ug | — |