drugset / Trial / NCT05418309

Tilelizumab Combined With Nab-Paclitaxel for High-Risk Non-Muscle-Invasive Urothelial Bladder Carcinoma Which is Not Completely Resectable: a Multi-center Study

NCT05418309 ↗

Phase 2 Unknown 63 enrolled Tianjin Medical University Second Hospital
NaSingle-groupOpen-labelTreatment

Summary

This is a phase II study to determine the safety and efficacy of tislelizumab when given in combination with nab-paclitaxel as treatment for patients with high-risk non-muscle-invasive bladder cancer (HR NMIBC) which is not completely resectable. Patients will receive treatment with tislelizumab in combination with nab-paclitaxel every 3 weeks for 4 treatment cycles over 12 weeks followed by transurethral resection biopsy.

Timeline

Start
2021-12-27
Primary completion
2024-02
Completion
2024-07

Drugs

EvaluationDrugModalityDoseRoute
Subject Nab-paclitaxel Small molecule 200 mg Intravenous
Subject Tislelizumab Monoclonal antibody 200 mg Intravenous