drugset / Trial / NCT05427149
The Effect of Intrathecal Magnesium Sulfate on Shivering
RandomizedParallel-groupSingle-blindTreatment
Summary
Shivering after spinal anesthesia is a common complication. Mangesium sulfate, which can be used intrathecally, is effective in preventing tremor. But what is the ideal dose?
Timeline
- Start
- 2022-05-10
- Primary completion
- 2022-06-30
- Completion
- 2022-08-30
Publications
- Background Ameta N, Jacob M, Hasnain S, Ramesh G. Comparison of prophylactic use of ketamine, tramadol, and dexmedetomidine for prevention of shivering after spinal anesthesia. J Anaesthesiol Clin Pharmacol. 2018 Jul-Sep;34(3):352-356. doi: 10.4103/joacp.JOACP_211_16.
- Background Hoshijima H, Takeuchi R, Kuratani N, Nishizawa S, Denawa Y, Shiga T, Nagasaka H. Incidence of postoperative shivering comparing remifentanil with other opioids: a meta-analysis. J Clin Anesth. 2016 Aug;32:300-12. doi: 10.1016/j.jclinane.2015.08.017. Epub 2015 Oct 1.
- Background Jayaraj A, Balachander H, Kuppusamy SK, Arusamy S, Rai Y, Siddiqui N. Comparison of meperidine, tramadol and fentanyl for post-spinal shivering prevention during cesarean delivery: A double-blind randomized controlled trial. J Obstet Gynaecol Res. 2019 Nov;45(11):2202-2208. doi: 10.1111/jog.14106. Epub 2019 Sep 4.
Drugs
| Evaluation | Drug | Modality | Dose | Route |
|---|---|---|---|---|
| Comparator | Magnesium Sulfate | Other / unclassified | 25 mg | Intrathecal |
| Comparator | Magnesium Sulfate | Other / unclassified | 50 mg | Intrathecal |
| Comparator | Magnesium Sulfate | Other / unclassified | 75 mg | Intrathecal |
| Comparator | Magnesium Sulfate | Other / unclassified | 100 mg | Intrathecal |
Indications
No indication recorded.