drugset / Trial / NCT05430048

Nasal Desmopressin Versus Oral Bisoprolol for Controlling Bleeding During Endoscopic Sinus Surgery

NCT05430048

Phase 2 Completed 100 enrolled Zagazig University
RandomizedParallel-groupTriple-blindTreatment

Summary

Functional endoscopic sinus surgery (FESS) is well established for treatment of chronic rhinosinusitis and nasal polyps. Masking of the surgical field can lead to severe complication as tissue injury, increase post-operative adhesions and scarring and even severe orbital and brain injury In the current study we will investigate the effect of nasal desmopressin versus oral bisoprolol for controlling bleeding and improving surgical field clarity during functional endoscopic sinus surgery

Timeline

Start
2022-07-01
Primary completion
2022-10-30
Completion
2022-11-05

Drugs

EvaluationDrugModalityDoseRoute
Comparator Bisoprolol Other / unclassified 2.5 mg Oral
Comparator Desmopressin Peptide 10 ug Intranasal

Indications