Conventional Versus Hypofractionated Radiotherapy With Temozolomide in Elderly Glioblastoma

Summary

In newly diagnosed glioblastoma patients aged 70 years or older who are suitable for concurrent temozolomide, the optimal dose of radiation therapy is controversial . The purpose of this study is to compare conventional radiotherapy of 60 Gy (6 weeks) versus hypofractionated radiotherapy of 40 Gy (3 weeks) in terms of overall survival as the primary endpoint along with progression-free survival, toxicity, quality of life, and prognostic biomarkers.

Timeline

Start

2025-02-01

Primary completion

2028-12-31

Completion

2030-12-31

Drugs

Indications