drugset

drugset / Trial / NCT05450718

Low-dose Buprenorphine Initiation for Opioid Use Disorder

NCT05450718 ↗

Phase 4 Recruiting 70 enrolled Montefiore Medical Center National Institute on Drug Abuse (NIDA) · collab

RandomizedParallel-groupOpen-labelTreatment

Summary

The purpose of this study is to test whether low-dose buprenorphine initiation for treatment of opioid use disorder is safe and effective.

Timeline

Start: 2024-11-11
Primary completion: 2027-03-17
Completion: 2027-06-30

Publications

Hayes BT, Sabado A, Minami H, Zhang C, Holm M, Khalid L, Lu TY, Torres-Lockhart K, Fox AD. MiBUP: A pilot randomized controlled trial of low-dose initiation of buprenorphine for opioid use disorder: Design and rationale. Contemp Clin Trials Commun. 2026 Jan 5;49:101594. doi: 10.1016/j.conctc.2026.101594. eCollection 2026 Feb.

Drugs

Evaluation	Drug	Modality	Dose	Route
Comparator	Buprenorphine	Other / unclassified	16 mg	Subcutaneous
Comparator	Buprenorphine	Other / unclassified	32 mg	Subcutaneous

Indications