Can Biotin Supplementation be Used to Mask hCG Abuse?

Summary

This sponsor is an anti-doping laboratory tasked with testing athlete samples for prohibited substances by the World Anti-Doping Agency and other agencies. This study is intended to measure: 1. Urinary/serum hCG (human chorionic gonadotropin) and urinary biotin concentrations in both treatment groups before, during, and after hCG intervention using standard immunoassay methods 2. To monitor hCG in both treatment groups before and after diafiltration of urine samples prior to analysis 3. To compare urinary and serum detectability (detection window, sensitivity) of hCG abuse in the hCG-only group compared to the hCG + biotin group

Timeline

Start

2022-10-27

Primary completion

2023-02-02

Completion

2023-02-02

Publications

• Goodrum JM, Nair VS, Moore C, Crouch AK, Eichner D, Miller GD. Impact of Biotin Supplementation on Human Chorionic Gonadotropin Immunoassays Utilizing Biotin-Streptavidin Binding Methods in Urine. Clin Chem. 2023 Jul 5;69(7):754-762. doi: 10.1093/clinchem/hvad060.

Drugs

Indications

No indication recorded.