A Study of Eptinezumab in Participants With Migraine and Medication Overuse Headache

Summary

Medication overuse headache (MOH) is a type of headache caused by excessive use of acute headache or migraine medications (medications used to treat a headache or migraine once it begins). Treatment of MOH usually involves reducing the dose of or discontinuing acute medications. Eptinezumab is a medication used for the preventive treatment of migraine in adults. The main goals of this trial are to learn whether eptinezumab helps reduce the number of days with migraine, the number of days with headache, and acute medication use in adults who have migraine and MOH.

Timeline

Start

2022-07-01

Primary completion

2024-10-22

Completion

2025-03-13

Publications

• Schytz HW, Jensen RH, Lundqvist C, Tassorelli C, Vernieri F, Lanteri-Minet M, Terwindt GM, Blumenfeld A, Tepper SJ, Josiassen MK, Jansson G, Ettrup A, Mittoux A, Lipton RB. Efficacy and safety of eptinezumab in adults with chronic migraine and medication-overuse headache who also received patient education: 24-week results of the randomized RESOLUTION trial. J Headache Pain. 2026 Jun 13;27(1):157. doi: 10.1186/s10194-026-02423-x.
• Tepper SJ, Schytz HW, Jensen RH, Lundqvist C, Terwindt GM, Tassorelli C, Vernieri F, Lanteri-Minet M, Blumenfeld A, Josiassen MK, Jansson G, Ettrup A, Mittoux A, Lipton RB. Benefits of eptinezumab on patient-reported disease burden and health-related quality of life in adults with chronic migraine and medication-overuse headache: Results from the placebo-controlled RESOLUTION trial. Cephalalgia. 2026 May;46(5):3331024261449814. doi: 10.1177/03331024261449814. Epub 2026 May 16.
• Jensen RH, Lundqvist C, Schytz HW, Tassorelli C, Vernieri F, Lanteri-Minet M, Terwindt GM, Blumenfeld A, Tepper SJ, Josiassen MK, Jansson G, Ettrup A, Mittoux A, Lipton RB. Eptinezumab With Patient Education for Chronic Migraine and Medication-Overuse Headache: The Randomized, Placebo-Controlled RESOLUTION Trial. Neurology. 2026 Apr 28;106(8):e214863. doi: 10.1212/WNL.0000000000214863. Epub 2026 Mar 26.

Drugs

Indications