A Proof-of-concept Study to Examine QUC398 in Participants With Knee OA

Summary

The purpose of the study was to find out if the investigational treatment named QUC398 had beneficial effects on osteoarthritis (OA) knee pain and knee cartilage, and if it was safe and tolerated.

Timeline

Start

2022-11-09

Primary completion

2024-08-02

Completion

2025-04-08

Outcome

Missed primary endpoint

Stopped (Business): “Sponsor Decision”

registry analysis (superiority test); QUC398 300 mg vs Placebo; p = 0.9961; Least Square Mean -8.5249 (90% CI -13.7 to -3.3) NCT05462990 ↗

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	QUC398	Unknown	300 mg	Subcutaneous

Indications