Efficacy of Trypsin-Chymotrypsin On Post-operative Pain After Single Visit Root Canal Treatment

Phase 4 Completed 60 enrolled Ain Shams University

RandomizedParallel-groupTriple-blindTreatment

Summary

Achieving effective pain control after endodontic treatment is still a disruptive event to all the clinicians. There is a knowledge gap regarding the effect of protease on postoperative pain following root canal treatment, therefore, the efficacy of Trypsin-Chymotrypsin on post endodontic pain was evaluated clinically in a randomized triple-blind trial.

Timeline

Start: 2021-06-01
Primary completion: 2021-12-31
Completion: 2021-12-31

Publications

Hashem AAR, Abd El Sattar AA, Abdel Rahman TY. The Effect of Trypsin-Chymotrypsin on Postoperative Pain after Single Visit Endodontic Treatment: A Randomized Controlled Trial. J Endod. 2023 Mar;49(3):240-247. doi: 10.1016/j.joen.2022.12.010. Epub 2022 Dec 24.

Drugs

Evaluation	Drug	Modality	Dose	Route
Subject	Chymotrypsin	Protein / enzyme biologic	5 mg	—
Subject	Ibuprofen	Small molecule	600 mg	—
Subject	TRYPSIN, CRYSTALLIZED	Protein / enzyme biologic	5 mg	—

Indications

No indication recorded.