Effects of Contrast Media Temperature on Image Quality and Clinical Adverse Events in Coronary CTA

Summary

Extrinsic prewarming of iodinated CT contrast media (CM) to body temperature reduces viscosity and injection pressures. However, guideline recommendations on the necessity to prewarm iodinated CM are conflicting. And studies examining the effect of extrinsic warming CM for coronary CTA(CCTA) on clinical adverse events and image quality are lack. Enrolled patients of chest pain or coronary artery disease screening were eligible for this a double-blinded, randomized noninferiority trial, and equally allocated into two group randomly: BBT-CM (basic body temperature) group received 37°C CM; RT-CM (room temperature) group received \~23°C CM. A state-of-the-art individualized CM (iopamidol at 370 mg I/mL) injection protocol was used, based on body weight.

Timeline

Start

2022-02-01

Primary completion

2023-01-01

Completion

2023-02-28

Publications

• Background Basharat NF, Ranganathan K, Kang PT, Gridley DG, Roh AT. Effect of Extrinsic Warming of Low-Osmolality CT Contrast Media (Iohexol 350) on Extravasations and Patient Reaction Rates: A Retrospective Study. AJR Am J Roentgenol. 2022 Jan;218(1):174-179. doi: 10.2214/AJR.21.26256. Epub 2021 Jul 28.
• Results Martens B, Wildberger JE, Van Kuijk SMJ, De Vos-Geelen J, Jeukens CRLPN, Mihl C. Influence of Contrast Material Temperature on Patient Comfort and Image Quality in Computed Tomography of the Abdomen: A Randomized Controlled Trial. Invest Radiol. 2022 Feb 1;57(2):85-89. doi: 10.1097/RLI.0000000000000807.
• Peng C, Liu Y, Zhang H, Xu G, He C, Jian D, Liu H, Li C, Zeng P, Wu H. Effects of extrinsically warmed contrast media on image quality and clinical adverse events in patients undergoing coronary computed tomography angiography: a randomized controlled trial. Quant Imaging Med Surg. 2026 Jan 1;16(1):13. doi: 10.21037/qims-2025-121. Epub 2025 Dec 31.

Drugs

Indications

No indication recorded.