drugset / Trial / NCT05499013

Study to Assess SLN124 in Patients With Polycythemia Vera

NCT05499013 ↗

Phase 1/2 Active not recruiting 69 enrolled Silence Therapeutics GmbH
RandomizedParallel-groupDouble-blindTreatment

Summary

This is a Phase 1/2, multicenter study with an open-label dose escalation followed by a randomized placebo controlled and double-blind phase of SLN124 in adult patients with Polycythemia Vera (PV) to assess the safety, tolerability, efficacy, pharmacokinetic (PK), and Pharmacodynamic (PD) response of SLN124.

Timeline

Start
2023-01-26
Primary completion
2026-09
Completion
2030-03

Drugs

EvaluationDrugModalityDoseRoute
Subject SLN124 Small interfering RNA (siRNA) — Subcutaneous