Sativex® and Gentamicin for Optimized Pharmagological Treatment in Older Patients (CanPan)

Summary

Malnutrition and inappropriate prescribing of renally excreted drugs are common among older persons and are associated with severe consequences such as complicated courses of treatment, mortality, and reduced quality of life. The overall purpose of CanPan is to optimize treatment of older persons with malnutrition with a focus on appetite stimulation and optimized prescribing of renal risk drugs. The CanPan trial consists of two sub-studies. Substudy 1 will provide knowledge on appetite and appetite stimulation and together, sub study 1 and 2 will offer unique knowledge on how body composition, renal function and biomarkers of organ function influence pharmacokinetics for a highly lipophilic (Sativex®) and hydrophilic (Hexamycin®) drug in older medical patients with malnutrition.

Timeline

Start

2022-03-24

Primary completion

2023-08-01

Completion

2023-09-01

Publications

• Nielsen RL, Bornaes O, Christensen LWS, Juul-Larsen HG, Storgaard IK, Kallemose T, Jorgensen LM, Jawad BN, Altintas I, Lund TM, Rasmussen HH, Munk T, Andersen O, Houlind MB, Andersen AL. The appetite stimulating effect and safety of delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in older patients with poor appetite: A triple-blinded, randomized, placebo-controlled, cross-over trial. Clin Nutr. 2025 Apr;47:248-257. doi: 10.1016/j.clnu.2025.02.024. Epub 2025 Feb 24.

Drugs

Indications